Abses Paru Pada Pasien Tuberkulosis Dengan Diabetes Melitus Yang Tidak Terkontrol
DOI:
https://doi.org/10.57218/jkj.Vol4.Iss1.1471Kata Kunci:
Pulmonary abscess, Tuberculosis, Uncontrolled diabetes mellitusAbstrak
The coexistence of tuberculosis (TB) and diabetes mellitus (DM) increases the risk of severe lung complications such as pulmonary abscess. Aim: This study evaluates the outcomes of such cases, emphasizing the effectiveness of combined therapeutic approaches. Methods: This retrospective study reviewed 121 patients diagnosed with TB and DM treated at a hospital in Depok City between January 2023 and April 2024. The study included four patients with confirmed lung abscesses. Diagnosis was established using clinical and supporting examination analyses. We monitored the patients for up to nine months after initiating treatment. All patients received standard TB and DM therapy along with intravenous antibiotics for two weeks and continued with oral antibiotics for six weeks. Results: Radiological findings consistently showed lung cavities with fluid levels and thick walls. Clinical outcomes demonstrated substantial improvement in all cases, with resolution of abscesses and symptom alleviation. Patients with lung abscesses who received early, combination treatment with antibiotics and medication for TB and DM had positive results. Conclusion: In our study, the administration of antibiotics for eight weeks, alongside simultaneous treatment for TB and DM, led to significant clinical improvement. Further research is warranted to management of lung abscesses in patients with TB and DM and intravenous antibiotics as the first-line approach.
Referensi
Ahmed, A. O., Ali, G. A., Goravey, W. (2022). Concomitant Pulmonary Tuberculosis and Invasive Aspergillosis Infection in an Immunocompetent Host. Eur J Case Rep Intern Med, 9(3), 003249.
Chan, P. C., Huang, L. M., Wu, P. S., et. al. (2005). Clinical Management and Outcome of Childhood Lung Abscess: A 16-Year Experience. J Microbiol Immunol Infect, 38, 183-188.
Choi, M. S., Chun, J. H., Lee, K. S., e.t al. (2015). Clinical Characteristics of Lung Abscess in Children: 15-Year Experience at Two University Hospitals. Korean J Pediatr, 58, 478-483.
Deng, A., Zhang, Z., He, M., Zhou, T. (2023). Acute Lung Abscess with Multiple Infections: A Refractory Case. Asian J Surg, 46(8), 3364-3365.
Feki, W., Ketata, W., Bahloul, N., et al. (2019). Lung Abscess: Diagnosis and Management. Rev Mal Respir, 36, 707-719. doi:10.1016/j.rmr.2018.07.010
Fernando, D. T., Bhatt, R., Saiganesh, A., et. al. (2022). Lung Abscess: 14 Years Of Experience in a Tertiary Pediatric Hospital. ANZ J Surg, 92(7-8), 1850-1855. doi: 10.1111/ans.17844.
Gupta, A., Dutt, N. (2015). A Study Profile of Lung Abscess Patients Coming To A Tertiary Care Center in Ahmedabad. Natl J Med Res, 5(4), 300-304.
Koziel, H., Koziel, M. J. (1995). Pulmonary Complications of Diabetes Mellitus: Pneumonia. Infect Dis Clin North Am, 9, 65-96.
Kuhajda, I., Zarogoulidis, K., Tsirgogianni, K., et. al. (2015). Lung Abscess: Etiology, Diagnostic, and Treatment Options. Ann Transl Med, 3(13):183.
Lee, J. H., Hong, H., Tamburrini, M., et. al. (2022). Percutaneous Transthoracic Catheter Drainage for Lung Abscess: A Systematic Review and Meta-Analysis. Eur Radiol, 32, 1184-1194. doi:10.1007/s00330-021-08149-5
Madhani, K., McGrath, E., Guglani, L. (2016). A 10-Year Retrospective Review of Pediatric Lung Abscesses from a Single Center. Ann Thorac Med, 11, 191-196. doi:10.4103/1817-1737.185763
Mandell, L. A., Wunderink, R. G., Anzueto, A., et. al. (2007). Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on The Management of Community-Acquired Pneumonia in Adults. Clin Infect Dis, 44(Suppl 2), S27-S72.
Mansharamani, N., Balachandran, D., Delaney, D., et. al. Lung Abscess in Adults: Clinical Comparison of Immunocompromised to Non-Immunocompromised Patients. Respir Med, 96(3), 178-85.
Mohapatra, M. M., Rajaram, M., Mallick, A. (2018). Clinical, Radiological and Bacteriological Profile of Lung Abscess: an Observational Hospital-Based Study. Open Access Maced J Med Sci, 6(9),1642-1646. doi:10.3889/oamjms.2018.374
Moreira J da, S., Camargo, J de J. P., Felicetti, J. C., et. al. (2006). Lung Abscess: Analysis of 252 Consecutive Cases Diagnosed Between 1968 And 2004. J Bras Pneumol, 32, 136-143.
Mwandumba, H. C., Beeching, N. J. (2000). Pyogenic Lung Infections: Factors for Predicting Clinical Outcome of Lung Abscess and Thoracic Empyema. Curr Opin Pulm Med, 6(3), 234-239. doi:10.1097/00063198-200005000-00012
Oliveira, A., Martins, L., Félix, M. (2015). Lung Abscesses in Children: 24 Years of Experience. Pulmonology, 21, 280-281.doi:10.1016/j.rppnen.2015.04.004
Prajapati, D. K., Modi, B., Nayudu, S. A., Patel, N. (2024). Clinical and Radiological Features of Lung Abscesses and Their Management: A Retrospective Observational Study. Journal of Clinical and Diagnostic Research, Vol-18(11): OC29-OC32
Sabbula, B. R., Rammohan, G., Sharma, S., Akella, J. (2022). Lung Abscess. Children (Basel), 9(7), 1047
Suleac, M., Naranjo, S., Djassi, M., Lavadinho, I. (2024). Necrotizing Pneumonia with Extensive Lobar Cavitation. Cureus, 16(3), e56437.
Takayanagi, N., Kagiyama, N., Ishiguro, T., et al. (2010). Etiology and Outcome of Community-Acquired Lung Abscess. Respiration, 80(2), 98-105.
Thomas, M., Vichita, O., Ruxandra, C., Ludovic, L., Ana, C., Michel, D. et al. (2021). Pyogenic Lung Abscess in an Infectious Disease Unit: A 20-Year Retrospective Study. Therapeutic Advances in Respiratory Disease, Jan-Dec:15:17534666211003012
Vaarst, J. K., Sperling, S., Dahl, V. N., et. al. (2023). Lung Abscess: Clinical Characteristics of 222 Danish Patients Diagnosed From 2016 To 2021. Respir Med, 216:107305. doi:10.1016/j.rmed.2023.107305
World Health Organization. Global Tuberculosis Report 2023. Geneva, Switzerland: World Health Organization; 2023.
Wu, Q., Liu, Y., Ma, Y.B., et. al. (2022). Incidence and Prevalence of Pulmonary Tuberculosis Among Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Ann Med, 54(1), 1657-1666.
Yazbeck, M. F., Dahdel, M., Kalra, A., et. al. (2014). Lung Abscess: Update on Microbiology and Management. Am J Ther, 21(3), 217-221.
Yen, C. C., Tang, R. B., Chen, S. J., Chin, T. W. (2004). Pediatric Lung Abscess: A Retrospective Review of 23 Cases. J Microbiol Immunol Infect, 37:45-49.
Yousef, L., Yousef, A., Al-Shamrani, A. (2022). Lung Abscess Case Series and Review of The Literature. Children (Basel), 9(7), 1047.
Yunus, M. (2009). CT-Guided Transthoracic Catheter Drainage of Intrapulmonary Abscess. J Pak Med Assoc, 59, 703-709.
Zhu, Y. M., Jiang, J., Jiang, T., et. al. Clinical Characteristics of Lung Abscess Caused by Streptococcus Constellatus Infection. Clin Lab, 70(7).doi:10.7754/Clin.Lab.2024.240329
