Hubungan Systemic Immune Inflammation Index dan Neutrophil-Lymphocyte Ratio Terhadap Skor PSI Pada Pasien Pneumonia Bakterial RS Adam Malik 2023

Penulis

  • Erna Debora Saing Universitas Sumatera Utara
  • Nelly Elfrida Samosir Universitas Sumatera Utara
  • Parluhutan Siagian Universitas Sumatera Utara
  • Ranti Permatasari Universitas Sumatera Utara
  • Ida Adhayanti Universitas Sumatera Utara
  • Sylvia Youvella Universitas Sumatera Utara

DOI:

https://doi.org/10.57218/jkj.Vol4.Iss3.2002

Kata Kunci:

NLR, Pneumonia bakterial, SII, Skor PS

Abstrak

Tujuan penelitian untuk mengetahui hubungan Systemic Immune-Inflammation Index (SII) dan Neutrophil-Lymphocyte Ratio (NLR) dengan skor Pneumonia Severity Index (PSI) pada pasien pneumonia bakterial di RS Adam Malik Medan. Penelitian ini merupakan studi analitik observasional dengan desain potong lintang menggunakan data sekunder dari rekam medis pasien pneumonia bakterial pada periode 1 Januari–31 Desember 2023. Seluruh subjek telah menjalani pemeriksaan darah lengkap, kultur darah/ sputum dan dilakukan perhitungan skor PSI. Nilai SII dihitung dari trombosit × neutrofil/limfosit, sedangkan NLR dari neutrofil/limfosit. Analisis data dilakukan menggunakan uji korelasi Spearman, dengan nilai p < 0,05 dianggap signifikan. Hasil penelitian menunjukan bahwa sebanyak 76 pasien diteliti, mayoritas laki-laki (67,1%) dengan usia rata-rata 57,78 tahun. Komorbid terbanyak adalah penyakit ginjal (11,8%) dan bakteri dominan Acinetobacter baumannii (15,8%). Rerata skor PSI 53,55, dengan median NLR 12,01 dan SII 2.385,79. Tidak terdapat hubungan signifikan antara NLR maupun SII dengan skor PSI. Kesimpulannya tidak terdapat hubungan yang signifikan  antara NLR dan SII terhadap skor PSI pada penelitian ini.

Referensi

Ardining, H., Indawati, W., & Uyainah, A. N. (2020). Pneumonia. In F. Liwang, P. W. Yuswar, E. Wijaya, N. P. Sanjaya, & 5th (Eds.), Kapita Selekta Kedokteran–Jilid I. Media Aesculapius.

Azmi, S., Aljunid, S. M., Maimaiti, N., Ali, A. A., Nur, A. M., Rosas-Valera, M. D., & al., et. (2016). Assessing the burden of pneumonia using administrative data from Malaysia, Indonesia, and the Philippines. Int J Infect Dis, 49, 87–93.

Calis, A. G., Ellison, R. T., Bennett, J. E., Dolin, R., & Blaser, M. J. (2020). Acute Pneumonia. In 9th (Ed.), Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Elsevier.

Ferreira-Coimbra, J., Sarda, C., & Rello, J. (2020). Burden of community-acquired pneumonia and unmet clinical needs. Adv Ther, 37(4), 1302–1318.

Huang, Y., Liu, A., Liang, L., & al., et. (2018). Diagnostic value of blood parameters for community-acquired pneumonia. Int Immunopharmacol, 64, 10–15.

Indonesia, K. K. R., & Kesehatan, B. P. dan P. (2019). Laporan Nasional Riset Kesehatan Dasar (Riskesdas) 2018. Kemenkes RI.

Ju, M.-J., Qiu, Y., Su, Y., Tu, G.-W., He, H.-Y., Gu, Z.-Y., Yang, C., & Luo, Z. (2020). Neutrophil-to-Lymphocyte Ratio Predicts Mortality in Adult Renal Transplant Recipients with Severe Community-Acquired Pneumonia. Pathogens, 9(11), 913. https://doi.org/10.3390/pathogens9110913

Kuikel, S., Pathak, N., Poudel, S., Thapa, S., Bhattarai, S. L., Chaudhary, G., & al., et. (2022). Neutrophil-lymphocyte ratio as a predictor of adverse outcome in patients with community-acquired pneumonia: a systematic review. Health Sci Rep, 5(3), e630.

Lim, W. S. (2022). Pneumonia—Overview. In Encyclopedia of Respiratory Medicine (pp. 185–197).

McAllister, D. A., Liu, L., Shi, T., Chu, Y., Reed, C., Burrows, J., & al., et. (2019). Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis. Lancet Glob Health, 7(1), e47–e57.

Méndez, R., Menéndez, R., Amara-Elori, I., Feced, L., Piro, A., Ramirez, P., & al., et. (2019). Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality. J Infect, 78(6), 423–431.

Miyashita, K., Nakatani, E., Hozumi, H., Sato, Y., Miyachi, Y., & Suda, T. (2021). Risk factors for pneumonia and death in adult patients with seasonal influenza and establishment of prediction scores: a population-based study. Open Forum Infect Dis, 8(3).

Mujaković, A., Paralija, B., Lepara, O., Fajkić, A., Kurtović, A., & Prnjavorac, B. (2022). Can neutrophil to lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals? Med Glas (Zenica), 19(2). https://doi.org/10.17392/1464 22

Pechous, R. D. (2017). With friends like these: the complex role of neutrophils in the progression of severe pneumonia. Front Cell Infect Microbiol, 7, 160.

Prabawa, I. M. D. W., Upeksha, A. A. G., & Pambudi, I. G. P. B. (2024). Hubungan Neutrophil-Lymphosit Ratio Terhadap Tingkat Keparahan Pneumonia Komunitas di RSUD Bali Mandara. Intisari Sains Medis, 15(2), 796–800. https://doi.org/10.15562/ism.v15i2.2055

Sharma, Y., Thompson, C., Zinellu, A., Shahi, R., Horwood, C., & Mangoni, A. A. (2025). The role of the neutrophil to lymphocyte ratio in predicting outcomes among patients with community acquired pneumonia. Clin Med (Lond), 25(1), 100278. https://doi.org/10.1016/j.clinme.2024.100278

Tanaka, S., Inoue, M., Yamaji, T., Iwasaki, M., Minami, T., Tsugane, S., & Sawada, N. (2023). Increased risk of death from pneumonia among cancer survivors: A propensity score-matched cohort analysis. Cancer Medicine, 12(6), 6689–6699. https://doi.org/10.1002/cam4.5456

Tortum, F., Tekin, E., & Ozdal, E. (2023). Use of the systemic immune-inflammation index to predict the severity of pneumonia in the emergency department. Med Res J, 8(3), 186–191.

Wang, S., Wan, Y., & Zhang, W. (2024). The clinical value of systemic immune inflammation index (SII) in predicting the severity of hospitalized children with Mycoplasma pneumoniae pneumonia: a retrospective study. Int J Gen Med, 17, 935–942. https://doi.org/10.2147/IJGM.S451466

Xie, M., Yuan, K., Zhu, X., Chen, J., Zhang, X., Xie, Y., & al., et. (2023). Systemic immune-inflammation index and long-term mortality in patients with stroke-associated pneumonia. J Inflamm Res, 16, 1581–1593.

Yang, T., Wan, C., Wang, H., Qin, J., Chen, L., Shen, Y., & Wen, F. (2017). The prognostic and risk-stratified value of neutrophil–lymphocyte count ratio in Chinese patients with community-acquired pneumonia. Eur J Inflamm, 15(1), 22–27.

Unduhan

Diterbitkan

2025-10-31