Alopesia Androgenetik: Mengenali Manifestasi Klinis Hingga Tatalaksana
DOI:
https://doi.org/10.57218/jkj.Vol1.Iss2.397Kata Kunci:
Alopesia androgenetik, Finasteride, Minoxidil, Transplantasi rambutAbstrak
Alopesia androgenetik (AAG) merupakan kondisi kerontokan rambut progesif yang menjadi penyebab umum pasien datang berkonsultasi terkait masalah rambut. AAG ditandai dengan miniaturisasi rambut dan distribusi kerontokan rambut yang khas. Predisposisi genetik dan hormon androgen disebutkan sebagai etiologi yang mendasari AAG. AAG mempengaruhi hampir 50% populasi pria maupun wanita. Meskipun AAG merupakan kondisi yang umum terjadi, namun pilihan terapi yang direkomendasikan masih terbatas. Terapi farmakologi dengan finasteride dan minoxidil hingga saat ini masih menjadi pilihan. Terapi non farmakologi AAG berupa terapi sinar dan transplantasi rambut. Kondisi AAG dapat menimbulkan tekanan psikologis dan rasa tidak percaya diri pada penderitanya.
Referensi
Ahmed, O. A. A., & Rizq, W. Y. (2018). Finasteride nano-transferosomal gel formula for management of androgenetic alopecia : ex vivo investigational approach. Drug Design, Development and Therapy, 2259–2265.
Akoh, C. C., & Sukhdeo, K. (2020). Finasteride Counseling for Male Androgenetic Alopecia Should Reflect Updated Findings on Prostate Cancer Risk. Skin Appendage Disorders, 6, 130–131. https://doi.org/10.1159/000504893
Choi, N., Shin, S., Song, S. U., & Sung, J. H. (2018). Minoxidil promotes hair growth through stimulation of growth factor release from adipose-derived stem cells. International Journal of Molecular Sciences, 19(691), 1–15. https://doi.org/10.3390/ijms19030691
Cranwell, W., & Sinclair, R. (2016). Male Androgenetic Alopecia. In Hair Disorders: Diagnosis and Management. MDText.com, Inc. https://doi.org/10.1201/9780429465154-2
Gupta, M., & Mysore, V. (2016). Classifications of patterned hair loss: a review. Journal of Cutaneous and Aesthetic Surgery, 9, 3–12. https://doi.org/10.4103/0974-2077.178536
He, F., Shen, M., Zhao, Z., Liu, Y., Zhang, S., Tang, Y., Xie, H., Chen, X., & Li, J. (2022). Epidemiology and disease burden of androgenetic alopecia in college freshmen in China: A population-based study. PLoS ONE, 17(2), 1–10. https://doi.org/10.1371/journal.pone.0263912
Ho, C. H., Sood, T., & Zito, P. M. (2021). Androgenetic Alopecia. StatPearls Publishing.
Inadomi, T. (2014). Efficacy of finasteride for treating patients with androgenetic alopecia who are pileous in other areas: A pilot study in Japan. Indian Journal of Dermatology, 59(2), 163–165. https://doi.org/10.4103/0019-5154.127677
Kelly, Y., Blanco, A., & Tosti, A. (2016). Androgenetic Alopecia: An Update of Treatment Options. Drugs, 76(14), 1349–1364. https://doi.org/10.1007/s40265-016-0629-5
Martinez-Jacobo, L., Villarreal-Villarreal, C. D., Ortiz-López, R., Ocampo-Candiani, J., & Rojas-Martínez, A. (2018). Genetic and molecular aspects of androgenetic alopecia. Indian Journal of Dermatology, Venereology and Leprology, 84(3), 263–268.
National Center for Biotechnology Information. (2022). Finasteride. https://pubchem.ncbi.nlm.nih.gov/compound/Finasteride
Nestor, M. S., Ablon, G., Gade, A., Han, H., & Fischer, D. L. (2021). Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. Journal of Cosmetic Dermatology, 20(12), 3759–3781. https://doi.org/10.1111/jocd.14537
Perera, E., & Sinclair, R. (2015). Androgenetic Alopecia. In S. Sacchidanand & S. Somiah (Ed.), Scalp and its disorders (hal. 1–13). Jaypee Publ. https://doi.org/10.3109/9781439808078-33
Shivakumar, S., Kassir, M., Rudnicka, L., Galadari, H., Grabbe, S., & Goldust, M. (2021). Hair transplantation surgery versus other modalities of treatment in androgenetic alopecia: A narrative review. Cosmetics, 8(25), 1–7. https://doi.org/10.3390/cosmetics8010025
Starace, M., Orlando, G., Alessandrini, A., & Piraccini, B. M. (2019). Female Androgenetic Alopecia: An Update on Diagnosis and Management. American Journal of Clinical Dermatology, 21(1), 69–84. https://doi.org/10.1007/s40257-019-00479-x
Stephanie, A. (2018). Tatalaksana Alopesia Androgenetik. CDK-267, 45(8), 582–587.
Suchonwanit, P., Thammarucha, S., & Leerunyakul, K. (2019). Minoxidil and its use in hair disorders: A review. Drug Design, Development and Therapy, 13, 2777–2786. https://doi.org/10.2147/DDDT.S214907
Vasudevan, B., Neema, S., Ghosh, K., Singh, S., & Khera, A. (2020). Hair transplantation by follicular unit extraction for male androgenetic alopecia: A retrospective observational study from two centers. Medical Journal Armed Forces India, 76(4), 430–437. https://doi.org/10.1016/j.mjafi.2019.11.001
Zito, P., Bistas, K., & Syed, K. (2022). Finasteride. StatPearls Publishing.
Zulaichah, N., Trisnowati, N., & Kusumawardani, A. (2017). Hubungan Antara Resistensi Insulin Dengan Alopesia Androgenetik pada Laki-Laki di RSUD Dr. Moewardi Surakarta. Media Dermato-Venerologika Indonesiana, 44(2), 74–78.
